Postoperative delirium
Conditions
Interventions
TIVA group(total-intravenous anesthesia group):intravenous administrations of propofol (4 - 12mg/kg/h) or ciprofol (0.8 - 2.4 mg/kg/h)
IHA group(inhalational anesthesia group):inhalation anesthesia of desflurane of sevoflurane
CIVIA group(combination of intravenous anesthesia and inhalation anesthesia ):combination anesthesia of inhalation and intravenous administration
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
80 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Provision of written informed consent; 2.Planned for elective non-cardiac surgery; 3.Patients of American Society of Anesthesiologists physical status I-IV (ASA I-IV). 4.Duration of surgery lasting over 1hour; 5.Aged over 80;
Exclusion criteria
Exclusion criteria: 1.Patients undergoing emergency, ambulatory, cardiac, or neurosurgical procedures. 2.Body mass index (BMI) = 45kg/m2; 3.Chronic use of sedatives, antidepressants, or hypnotics; 4.Inability to complete cognitive assessments due to hearing impairment, language barriers, or other communication limitations; 5.History of malignant hyperthermia; 6.Neuromuscular disease; 7.Alcohol or substance abuse; 8.Any condition that the investigator considers incompatible with safe participation or reliable follow-up;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| severity of postoperative delirium;Sleep quality;Length of stay in the ICU;Long-term postoperative changes in cognitive function;Pain scores;PONV;Intraoperation hypotension;Requirement for supplemental oxygen;All-cause mortality;Recovery quality;Length of stay in hospital; | — |
Countries
China
Contacts
Public ContactQianzi Yang
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed