Postoperative delirium
Conditions
Interventions
Experimental group:The experimental group received percutaneous auricular vagus nerve stimulation intervention during the perioperative period. The stimulation site was the vagus nerve distribution ar
Control group:The control group received sham stimulation at the same time points and locations, with identical stimulation protocols and electrode placement as the experimental group, but without gen
Sponsors
The Second Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years, scheduled for elective gastrointestinal tumor surgery; 2. ASA physical status classification of I–III; 3. Preoperatively determined to be cooperative for assessment via educationally adjusted MMSE and clinical evaluation, with no moderate/severe cognitive impairment; 4. Signed informed consent and voluntarily participated in the study.
Exclusion criteria
Exclusion criteria: 1. Implantation of cardiac pacemakers, implantable cardioverter-defibrillators, deep brain stimulators, or other electronic/magnetic devices within the body; 2. History of epilepsy diagnosis or seizures within the past 6 months; history of cerebrovascular disease (such as cerebral infarction or cerebral hemorrhage); 3. Severe/unstable cardiovascular disease (e.g., myocardial infarction within the past 3 months, progressive heart failure, resting heart rate 7 points); 6. Currently using potent sedatives, antipsychotics, or potent anticholinergic drugs that cannot be maintained at stable levels during the study period; 7. Participation in other clinical trials or receipt of taVNS/invasive VNS therapy within the past 2 weeks prior to enrollment; 8. Individuals with infectious diseases, such as hepatitis B, syphilis, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium incidence rate;Perioperative EEG Parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative Inflammatory and Neurological Markers;Time required for gastrointestinal function recovery after surgery;Changes in Sleep Quality After Surgery;Anxiety and Depression State;Postoperative Pain Score;Incidence of adverse events and serious adverse events; | — |
Countries
China
Contacts
Public ContactHua Fuzhou
The Second Affiliated Hospital of Nanchang University
Outcome results
None listed