Postoperative complications of the central nervous system
Conditions
Interventions
Intervention group:Transcutaneous auricular vagus nerve stimulation (taVNS)
Sponsors
The First Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-85 years, regardless of gender. 2. Scheduled for elective cardiac surgery, including coronary artery bypass grafting, cardiac valve replacement/repair, combined coronary artery bypass grafting and valve replacement, etc. 3. New York Heart Association (NYHA) functional class I-III. 4. The patient or their authorized representative voluntarily signs the informed consent form, agrees to participate in this study, and cooperates with the completion of all observational indicators. 5. Surgery duration >= 2 hours, and the patient can tolerate the placement and stimulation of the transcutaneous auricular vagus nerve stimulation electrode during the procedure.
Exclusion criteria
Exclusion criteria: 1. Patients with other interfering factors affecting cognitive assessment, such as a preoperative MMSE score < 24; severe language, hearing, or visual impairments that cannot be compensated for with auxiliary means and thus hinder cooperation with assessments. 2. History of previously diagnosed delirium, dementia, Parkinson’s disease, schizophrenia, bipolar disorder, major depressive disorder, or other cognitive or psychiatric disorders; long-term use of psychotropic medications (e.g., antipsychotics, anxiolytics, antidepressants, sedative-hypnotics) that cannot be discontinued or adjusted. 3. Presence of skin lesions, infections, ulcers, keloids, severe dermatitis, or congenital deformities in both ears that prevent effective fixation of the taVNS electrodes; history of ear surgery or neural damage in the ear; allergy to taVNS electrode materials or conductive gel. 4. Concurrent severe cardiac arrhythmias; implantation of electronic devices such as cardiac pacemakers, implantable cardioverter-defibrillators, or deep brain stimulators. 5. Participation in other interventional clinical studies within the past 3 months; other circumstances deemed by the investigator as unsuitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of postoperative depression;The incidence of postoperative anxiety;sedation-agitation scale;Postoperative Pain;Postoperative sleep disorders; | — |
Countries
China
Contacts
Public ContactMi Weidong
The First Medical Center of Chinese PLA General Hospital
Outcome results
None listed