Postoperative urinary retention
Conditions
Interventions
Opioid-free anesthesia group:For anesthesia induction, midazolam 0.05 mg/kg, propofol 2 mg/kg, rocuronium 0.6-0.9 mg/kg, etomidate 0.7 mg/kg (administered in two doses, one before intubation and the o
Opioid anesthesia group:For anesthesia induction, midazolam 0.05 mg/kg, propofol 2 mg/kg, rocuronium 0.6-0.9 mg/kg, and sufentanil 0.7 ug/kg were used. 3-5 minutes after anesthesia induction, tracheal
Sponsors
Huai'an Hospital of Huai'an City
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female patients undergo elective laparoscopic cholecystectomy; 2. Age between 18 and 65 years; 3. ASA grade I to III; 4. Body Mass Index (BMI) ranging from 18 to 30 kg/m^2; 5. Capable of listening, speaking, reading, writing and communication; 6. Clearly understand and voluntarily participate in this study, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have contraindications or allergies to esketamine or other study drugs; 2. There is a significant risk of intracranial pressure elevation such as intracranial aneurysm, uncontrolled hypertension or untreated hypertension (systolic blood pressure exceeding 180 mmHg and diastolic blood pressure exceeding 100 mmHg at rest), untreated or insufficient treatment of hyperthyroidism, combined ischemic heart disease, unstable angina or myocardial infarction in the past 6 months, combined congestive heart failure, combined high intraocular pressure (such as glaucoma) and penetrating ocular trauma; 3. Severe liver (Child-Pugh C grade) and kidney (creatinine clearance rate < 30 ml/min) dysfunction; 4. Severe cardiovascular and cerebrovascular diseases (myocardial infarction, cardiac arrest, decompensated heart failure, second-degree or higher atrioventricular conduction block without pacemaker, congenital heart disease, severe valvular disease, massive cerebral hemorrhage or cerebral infarction, etc.) and respiratory diseases (history of asthma, acute exacerbation of COPD, history of lung resection surgery, etc.); 5. History of mental disorders; 6. Long-term history of mental drugs, sedatives, analgesics or antidepressants before the operation; 7. Patients who refuse to participate or the investigator deems it inappropriate for them to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative urinary retention;The severity of postoperative urinary retention (the amount of urine drained after inserting the urinary catheter); | — |
Secondary
| Measure | Time frame |
|---|---|
| The mean arterial pressure;heart rate;The usage of vasoactive drugs during the perioperative period (drug name, dosage);The time of the first request for pain relief after the surgery and the dosage of the pain medication used;Postoperative NRS pain scores (immediately after extubation, when leaving the PACU, 12 hours after leaving the PACU, 24 hours after leaving the PACU, and 48 hours after leaving the PACU);Awakening time;Extubation time;Duration of stay in the PACU;Postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactTeng He
Huai'an Hospital of Huai'an City
Outcome results
None listed