Infertility
Conditions
Interventions
Trial Group:Intravenous fentanyl citrate 8µg/kg, slow intravenous injection (infusion time 30s), combined with propofol target-controlled infusion (TCI) anesthesia.
Control Group:Intravenous fentanyl 1.2µg/kg, slow intravenous injection (infusion time 30s), combined with propofol target-controlled infusion (TCI) anesthesia.
Sponsors
Reproductive Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
Female
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. ASA physical status classification I–II, BMI 18–28 kg/m², and operative time =15 minutes. 2. Patient is conscious, able to communicate effectively with physicians, and can understand the Visual Analogue Scale (VAS) under medical guidance. 3. Normal preoperative routine electrocardiogram (ECG) and hepatic/renal function tests. 4. No history of cardiovascular diseases, such as hypertension or coronary artery disease. 5. No severe hematological disorders. 6. No recent upper respiratory tract infection.
Exclusion criteria
Exclusion criteria: 1. History of long-term use of narcotic analgesics, sedatives, or non-steroidal anti-inflammatory drugs (NSAIDs). 2. History of neurological or psychiatric disorders prior to surgery. 3. Patients with a history of habitual gastroesophageal reflux or vomiting.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diaphragmatic excursion;Incidence of apnea; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate, mean arterial pressure, respiratory rate, oxygen saturation;End-tidal carbon dioxide;Propofol induction dose, effect-site concentration, bolus, total dose;Surgical duration, emergence time, number of oocytes retrieved;Perioperative adverse events (hypoxemia, respiratory depression, hypotension, bradycardia, nausea and vomiting, dizziness, visual disturbance);Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score;Visual Analogue Scale (VAS) score;Patient comfort score, surgeon satisfaction score;Safety outcomes (including perioperative adverse events: hypoxemia, respiratory depression, hypotension, bradycardia, nausea and vomiting, dizziness, visual disturbance; vital signs monitoring: heart rate, mean arterial pressure, respiratory rate, oxygen saturation, end-tidal carbon dioxide); | — |
Countries
China
Contacts
Public ContactChuanxia Feng
Guangxi Zhuang Autonomous Region Reproductive Hospital
Outcome results
None listed