Colorectal Cancer
Conditions
Interventions
Investigational group:Consumption of yogurt containing Limosilactobacillus fermentum GR-3.
Control group:Consumption of yogurt identical in appearance and formulation to the study product, except that it does not contain Limosilactobacillus fermentum GR-3.
Sponsors
The Second Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: Histopathologically confirmed colorectal cancer. Prior to screening, participants must be fully informed and provide written informed consent. Aged 18–79 years, with no restrictions on sex. Scheduled to undergo curative (radical) surgical resection. Eastern Cooperative Oncology Group (ECOG) performance status of 0–1.
Exclusion criteria
Exclusion criteria: Individuals with a history of severe allergy to the main ingredients or excipients of probiotic fermented dairy products, or with an allergic constitution. Receipt of any live attenuated vaccine within 30 days prior to the first dose. Inability to swallow the study product normally, or presence of malabsorption syndrome, or other conditions that preclude intestinal absorption of the study product or may interfere with the absorption of GR-3. Known drug abuse or alcohol abuse. Pregnant or breastfeeding women. Any other condition or circumstance that, in the investigator’s judgment, makes the participant unsuitable for enrollment in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abundance of key microbial taxa;Intestinal barrier indicator D-lactate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory cytokines;Key metabolites; | — |
Countries
China
Contacts
Public ContactWang Na
The Second Hospital of Lanzhou University
Outcome results
None listed