Bariatric surgery
Conditions
Interventions
Sufentanil Group:Sufentanil used for induction and maintenance of anesthesia
sufentanil 0.1 ug/kg administered 20 minutes before surgery end
PCA pump connected (100 ug sufentanil + 8 mg ondansetron diluted to 100 ml with normal saline)
background infusion rate of 2 ml/h, bolus dose of 1 ml per request, lockout interval of 10 minutes.
Tegidilid Group:Tegidilid 0.01 mg/kg administered 20 minutes before surgery end
PCA pump connected (5 mg tegidilid + 8 mg ondansetron diluted to 100 ml with normal saline)
Sponsors
Fuyang Hospital Affiliated to Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing laparoscopic bariatric surgery. 2. Aged 18–65 years. 3. BMI >= 28 kg/m^2. 4. ASA physical status classification Grade I–III.
Exclusion criteria
Exclusion criteria: 1. Unwilling to participate or unable to sign the informed consent form. 2. Complicated with obstructive sleep apnea syndrome. 3. History of chronic pain. 4. Severe cardiovascular or pulmonary diseases. 5. Prolonged Q-T interval. 6. Hypersensitivity to any study medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS scores at rest and during activity at 30 min, 2 h, 6 h, 12 h, 24 h, and 48 h post-extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of patient-controlled analgesia pump presses;Rescue analgesia requirement; | — |
Countries
China
Contacts
Public ContactZhao Yuanyuan
Fuyang Hospital Affiliated to Anhui Medical University
Outcome results
None listed