Adjuvant stage IIIb after colorectal cancer surgery
Conditions
Interventions
Transcranial magnetic stimulation (TMS) treatment group:TMS-EEG/fNIRS (transcranial magnetic stimulation - electroencephalography / functional near-infrared spectroscopy) multimodal closed-loop stimul
False stimulation group:Transcranial magnetic stimulation coil intervention
Sponsors
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.The patient voluntarily joined this study, signed the informed consent form, and had good compliance. 2.Aged 18 and above, no gender restrictions. 3.After histological or cytological confirmation of colorectal adenocarcinoma, and when surgery is feasible; 4.ECOG performance score of 0 to 3; 5.The score of the Hamilton Depression Rating Scale (HAMD) is >= 8 points. 6.There is no unconsciousness disorder, with the ability of autonomous behavior, capable of signing the informed consent form and able to follow the research protocol. 7.The estimated survival period is >= 3 months. 8.Before enrollment, no antidepressants had been taken and no electroconvulsive therapy had been performed.
Exclusion criteria
Exclusion criteria: 1. Anxiety and depression caused by somatic factors, such as cancer pain, as evaluated by the researchers; 2. Those with severe cognitive impairment or active psychosis; 3. Those who have participated in other drug clinical trials within the past four weeks; 4. Those with unhealed head wounds that prevent them from wearing a head ring; 5. Those with high fever or severe infection, cachexia, multiple organ failure, or inability to cooperate; 6. Women who are breastfeeding or pregnant; 7. Other conditions deemed unsuitable for TMS-EEG/fNIRS multimodal closed-loop stimulation by a multidisciplinary team; 8. Those with a history of mania; 9. Those with severe suicidal or self-harming thoughts or behaviors; 10. Those with implanted cardiac pacemakers or metal objects in the brain; 11. Those with a history of epilepsy or cranial surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale (HAMD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptom Checklist 90 (SCL-90);Pittsburgh Sleep Quality Index (PSQI);Hamilton Anxiety Scale (HAMA); | — |
Countries
China
Contacts
Public ContactGu Yanhong
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Outcome results
None listed