Primary malignant tumor of the kidney
Conditions
Interventions
Zero ischemia group:Zero ischemia
Cold ischemia group:Cold ischemia
Warm ischemia group:Warm ischemia group
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients with renal cell carcinoma (RCC) who are highly suspected by pathology or imaging and are scheduled for surgical resection, and meet the clinical diagnostic criteria for locally advanced or high-risk renal cell carcinoma; (YNMT)·; 2.Planned to undergo partial nephrectomy; 3.Complete clinical assessment data are available before the operation, including imaging examinations (such as enhanced CT, MRI, renal dynamic imaging, etc.) and laboratory indicators (such as renal function, tumor markers); 4.Age >=18 years old, gender not limited; 5.There are no other active malignant tumors, and no complications that seriously affect the safety of surgery or adjuvant therapy.
Exclusion criteria
Exclusion criteria: 1.Patients with non-renal cell carcinoma or those with an unclear pathological diagnosis; 2.Previously received systemic targeted therapy, immunotherapy or radiotherapy, and currently in the recurrence or extensive metastasis stage; 3.It is complicated with severe cardiopulmonary insufficiency, liver and kidney failure, active infection, etc., and cannot tolerate surgery or adjuvant therapy; 4.Combined with severe mental illness, cognitive impairment or other conditions that affect research compliance; 5.Unable to cooperate with postoperative follow-up or expected to be unable to complete relevant evaluations and data collection during the study period; 6.Currently participating in other interventional clinical studies that may interfere with the evaluation of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in estimated Glomerular Filtration Rate;Recurrence-Free Survival (RFS);;Overall Survival (OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative blood loss;Ischemia duration;Chronic kidney disease stage change;Perioperative complications;Incidence of AKI; | — |
Countries
China
Contacts
Public ContactQi Zhang
Zhejiang Provincial People's Hospital
Outcome results
None listed