Delirium
Conditions
Interventions
Experimental group:Enhanced Sedation and Analgesia Protocol
Control group:The routine sedation and analgesia protocol was implemented for ICU patients
Sponsors
Dalian University of Technology Affiliated Central Hospital (Dalian Central Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 80 years old (inclusive), with endotracheal intubation and mechanical ventilation treatment. 2.Receiving routine basic sedation and analgesia treatment. 3.Written informed consent signed by the subject or their legal representative.
Exclusion criteria
Exclusion criteria: 1.Unstable hemodynamics: Catecholamine Index (CAI) >= 20 µg/kg/min. 2.Pregnancy or lactation period. 3.Neurological/psychiatric abnormalities: (1) A history of severe mental illness or neurological dysfunction; (2) Presence of delirium upon ICU admission; (3) Complicated with cerebral diseases (e.g., stroke, brain tumor) or brain injury. 4.Severe hepatorenal impairment: Stage 4 chronic kidney disease (CKD) (glomerular filtration rate < 30 mL/min/1.73m^2), or liver function of Child-Pugh Class C or higher. 5.Patients with pressure injuries on the back and buttocks; patients requiring intensive airway management.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in CPOT pain scores;Time to first onset of delirium;Duration of delirium; | — |
Countries
China
Contacts
Public ContactYanxia Li
Dalian University of Technology Affiliated Central Hospital (Dalian Central Hospital)
Outcome results
None listed