Cerebral Oxygen Supply-Demand Balance and Postoperative Delirium
Conditions
Interventions
Group C:Disodium Phosphate Propofol
Group P:Propofol
Sponsors
Zigong First People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years, ASA I-III 2. Planned laparoscopic cholecystectomy. 3. Preoperative MMSE score >= 24 and 3D-CAM score less than 3 4. No severe liver or kidney dysfunction / neurological disorders / history of psychiatric illness 5. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe liver and kidney dysfunction 2. Neurological diseases (such as Parkinson's disease, history of stroke) or a history of psychiatric disorders 3. Allergy to the study drug or a history of serious adverse drug reactions 4. Expected conversion to open surgery during the operation 5. Refusal to sign the informed consent form 6. Preoperative MMSE score less than 24 or 3D-CAM score >= 3
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium within 3 days after surgery;Time to reach target BIS values during induction and surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in cerebral oxygen uptake rate;Agitation during PACU recovery;Severity duration and outcomes of POD in each group;Incidence of hypotension or hypertension during induction and surgery;TCD blood flow changes during induction and surgery;VAS scores from 4 8 PM on postoperative days 1 2 and 3;Blood analysis WBC neutrophils;Changes in IL 6 and NSE;Adverse events; | — |
Countries
China
Contacts
Public ContactQian Liu
Zigong First People's Hospital
Outcome results
None listed