Chronic kidney disease
Conditions
Interventions
Single-arm observational cohort:None
Sponsors
First Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients aged 18-80 years old; 2. The baseline estimated GFR is between 20 and 60ml/min.1.73m^2; 3. The urinary albumin creatinine ratio is greater than 100mg/g or the 24-hour urinary protein quantification is greater than 0.3g/d.
Exclusion criteria
Exclusion criteria: 1. Type I diabetes; 2. Polycystic kidney disease; 3. Lupus nephritis; 4. ANCA associated vasculitis; 5. Anti-glomerular basement membrane disease; 6. Previously underwent dialysis or kidney transplantation; 7. Urinary tract infections (including pyelonephritis, cystitis, prostatitis, urethritis, etc.); 8. Pregnant or lactating patients; 9. The patient did not sign the informed consent form; 10. The patient has received SGLT2 inhibitor treatment; 11. The patient has experienced acute kidney injury within one month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of eGFR decreasing by >= 10% from baseline after one month of SGLT2 inhibitor treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in urinary albumin/creatinine ratio (UACR);24-hour urinary protein quantification;eGFR absolute value change;eGFR slope; | — |
Countries
China
Contacts
Public ContactGuangyan Cai
First Medical Center of Chinese PLA General Hospital
Outcome results
None listed