Major depressive disorder
Conditions
Interventions
Adolescent Depression Patients with Early Stress:None
Adolescent Depression Patients without Early Stress:None
Healthy Control Group with Early Stress:None
Healthy Control Group without Early Stress:None
Sponsors
First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: Case Group: 1. Experience early stressful life events (childhood abuse and/or school bullying); 2. Meet the DSM-5 diagnostic criteria for major depressive disorder; 3. Age 12-17, gender unrestricted; 4. First episode if diagnosed, no prior antidepressant medication. Control Group: 80 controls aged 12-17 recruited via advertisements and community outreach, matched to the patient group in gender and years of education.
Exclusion criteria
Exclusion criteria: Case Group 1. Comorbid psychiatric disorders other than Axis I diagnoses; 2. Severe and unstable somatic diseases, including those of the cardiovascular, hepatic, renal, endocrine, hematologic, and autoimmune systems; 3. Current or history of neurological disorders, traumatic brain injury, or neurosurgical treatment; 4. Family history of psychiatric or neurological disorders; 5. History of alcohol or substance abuse and drug dependence within the past year; 6. Currently undergoing physical therapies (e.g., electroconvulsive therapy, transcranial magnetic stimulation) or systematic psychotherapy; 7. Pregnant, breastfeeding, or planning to become pregnant during the study period; 8. Estimated poor compliance or inability to cooperate; 9. Contraindications or unsuitability for MRI, such as metal implants or claustrophobia; 10. Congenital abnormalities (e.g., cavum septum pellucidum) or acquired white matter lesions (e.g., cerebrovascular disease, demyelinating diseases, neurodegenerative diseases) shown on T1-weighted MRI. Control Group 1. Current or history of somatic or neurological disorders; 2. Current or history of psychiatric disorders; 3. Family history of psychiatric disorders; 4. Current or history of substance abuse; 5. History of traumatic brain injury; 6. Contraindications for MRI; 7. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression scale score;Changes in serum S1P level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Structural and functional changes in head MRI; | — |
Countries
China
Contacts
Public ContactJiang Linling
First Affiliated Hospital of Kunming Medical University
Outcome results
None listed