Osteoporotic fracture
Conditions
Interventions
Control group:None
Sponsors
First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 45-75 years old. 2. No use of drugs affecting bone metabolism within the past 1 year: such as bisphosphonates, calcitonin, parathyroid hormone, glucocorticoids (usage>3 months), selective estrogen receptor modulators (SERMs), etc. 3. Indications for orthopedic surgery: Surgical resection of bone (e.g., vertebral bodies, facet joints, proximal femur, distal radius, proximal humerus), muscle (e.g., paravertebral muscles, hip muscle groups), and ligament (e.g., supraspinous ligament, interspinous ligament, posterior longitudinal ligament, intervertebral discs, ligamentum flavum) is required. Surgical procedures include spinal fusion, kyphoplasty, open reduction and internal fixation (ORIF) for hip fractures, total hip arthroplasty, and open reduction and internal fixation (ORIF) for radial and humeral fractures. 4. The patient is conscious, voluntarily signs the informed consent form, and cooperates with the completion of clinical data collection and follow-up.
Exclusion criteria
Exclusion criteria: 1. Bone metabolic disorders other than primary osteoporosis: such as osteogenesis imperfecta, osteomalacia, multiple myeloma, bone metastatic carcinoma, etc. 2. Chronic diseases affecting estrogen metabolism or bone health: diabetes mellitus (glycated hemoglobin>7.5%), rheumatoid arthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease (COPD), chronic kidney disease (CKD = stage 3), chronic liver disease, etc. 3. A history of major surgery, bone fracture, or strenuous exercise within the past 6 months (which may affect the state of the tissue transcription). 4. History of malignant tumors (within the past 5 years), psychiatric disorders, or cognitive dysfunction (impossibility of participating in the study). Alcohol dependence (daily consumption>25g) or smoking (daily>10 cigarettes, sustained for the past 10 years) (both affecting bone metabolism and gut microbiota).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gene sequencing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Routine biochemical indicators;Bone density test;Pathological examination; | — |
Countries
China
Contacts
Public ContactZheng Hongyu
First Affiliated Hospital of Kunming Medical University
Outcome results
None listed