Motor impairment of the affected upper limb after hemorrhage or ischemic stroke
Conditions
Interventions
Transcranial focused ultrasound stimulation group,tFUS:Active Low-Intensity Focused Ultrasound Stimulation Combined with Upper-Extremity Robotic Rehabilitation Training
Sham transcranial focused ultrasound stimulation group, sham-tFUS:Sham Low-Intensity Focused Ultrasound Stimulation Combined with Upper-Extremity Robotic Rehabilitation Training
Sponsors
Shanghai Yangzhi rehabilitation hospital
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1.Meets the diagnostic criteria of "2019 Key Points for Major Cerebrovascular Diseases in China" and is confirmed by cranial CT or MRI as cerebral infarction or cerebral hemorrhage; 2.First time, single lesion basal ganglia stroke patients; 3.Imaging shows intact thalamic structure in patients; 4.Individuals without cognitive impairment (MMSE score >= 27); 5.Individuals with upper limb motor dysfunction (FMA-UE<66 points); 6. The course of the disease is within 1-12 months; 7. The patient and their family are willing to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.head craniotomy surgery (incomplete skull); 2.Intracranial/intracorporeal metal implants (pacemakers, cochlear implants); 3.History of Epilepsy; 4.Taking psychotropic drugs;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment for Upper Extremity,FMA-UE; | — |
Secondary
| Measure | Time frame |
|---|---|
| fMRI Outcome Measures: Functional Connectivity and Brain Network Connectivity;ModifiedBarthel Index, MBI;rest-EEG/TMS-EEG Outcome Measures: TEP Amplitude, TMS-Induced Oscillations, Phase Coupling, Source-Space Current Density, Source-Space Current Scatter, and Perturbational Complexity Index;Wolf Motor Function Test, WMFT; | — |
Countries
China
Contacts
Public ContactBai Zhongfei
Shanghai Yangzhi rehabilitation hospital
Outcome results
None listed