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Continuous Infusion of Norepinephrine to Prevent Low Blood Pressure During Surgery in Elderly Patients with Cardiovascular Disease

Effect of Prophylactic Norepinephrine Infusion vs. Reactive Bolus on Intraoperative Hypotension Burden in Elderly Patients with Cardiovascular Disease

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600119704
Enrollment
Unknown
Registered
2026-03-02
Start date
2026-03-02
Completion date
Unknown
Last updated
2026-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraoperative Hypotension

Interventions

Reactive Bolus Group:Reactive Intravenous Bolus of Norepinephrine
Prophylactic Infusion Group:Prophylactic Continuous Infusion of Norepinephrine

Sponsors

Affiliated Hospital of Guangdong Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age: >=65 years, gender not limited; 2. ASA Classification: American Society of Anesthesiologists (ASA) physical status class II or III; 3. Cardiovascular Risk Characteristics: Preoperative coexistence of at least one cardiovascular risk factor, including essential hypertension, coronary artery disease (CCS class I-II), old cerebral infarction (> 3 months since onset), or diabetes mellitus; 4. Type of Surgery: Scheduled for elective major non-cardiac surgery under general anesthesia (e.g., major abdominal, thoracic, or orthopedic surgery), with an expected duration of >= 2 hours; 5. Ethical Consent: The patient or legal representative agrees to participate in the study and signs the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Severe arrhythmia: Preoperative ECG indicating frequent premature ventricular contractions (PVCs), second-degree type II atrioventricular block or higher, or atrial fibrillation with rapid ventricular rate (> 100 bpm); 2. Severe renal impairment: Patients who have received preoperative dialysis, or have preoperative serum creatinine >= 176 µmol/L (2.0 mg/dL); 3. Heart failure: Preoperative LVEF 35 kg/m² or 180 mmHg and refractory to medication; 8. Emergency surgery or participation in other clinical trials within the past 30 days.

Design outcomes

Primary

MeasureTime frame
Time-weighted average (TWA) of intraoperative hypotension;—

Secondary

MeasureTime frame
Incidence of Severe Hypertension Events;Lactate Clearance Rate at End of Surgery;Perioperative Urine Output;Relative Change Rate of eGFR at 24h Post-operation;Capillary Refill Time (CRT);—

Countries

China

Contacts

Public ContactTang Jing

Affiliated Hospital of Guangdong Medical University

tanglitangjing@126.com+86 13189091282

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026