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Research on Corneal Sensory Function in Children and Adults and Its Clinical Influencing Factors—Based on Cochet-Bonnet and Multimodal Measurement Methods

Research on Corneal Sensory Function in Children and Adults and Its Clinical Influencing Factors—Based on Cochet-Bonnet and Multimodal Measurement Methods

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600119700
Enrollment
Unknown
Registered
2026-03-02
Start date
2026-03-02
Completion date
Unknown
Last updated
2026-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myopia

Interventions

Groups with different contact lens wearing durations:None
Unworn control group:None

Sponsors

Tianjin Medical University Eye Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
8 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.Patients who visited the outpatient department and voluntarily underwent corneal sensory function assessment; 2.Children and adults; 3.Be able to understand the inspection instructions and cooperate to complete the measurements using the Cochet - Bonnet/non - contact corneal esthesiometer and confocal microscope, etc. 4.The patient himself/herself (or the guardian) is able to and willing to sign a written informed consent form.

Exclusion criteria

Exclusion criteria: 1.Acute active eye diseases: Patients with acute conjunctivitis, keratitis, scleritis, active uveitis, etc. may have their corneal sensitivity significantly affected by the inflammation itself or be unable to tolerate the examination. 2.History of recent eye surgery or trauma; 3.Severe ocular surface abnormalities that may affect the assessment: significant corneal opacity, scarring, pterygium, etc. are present. 4.History of neurological diseases: Known to have neurological diseases that affect corneal or facial sensation (such as trigeminal neuralgia, post - herpetic neuralgia, and diabetic peripheral neuropathy with definite ocular involvement). 5.Those who cannot cooperate with the examination.

Design outcomes

Primary

MeasureTime frame
Corneal sensory threshold;Tear proteomics analysis;Non-targeted metabolomic analysis of tear fluid;

Secondary

MeasureTime frame
Cumulative wearing time of contact lenses;SE;

Countries

China

Contacts

Public ContactRuihua Wei

Tianjin Medical University Eye Hospital

weirhua2009@126.com+86 139 2068 5016

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026