Hysteroscopic surgery pain
Conditions
Interventions
The Anrelifin combined with propofol group (Group A):Anrekefen (ED95 dose determined by pre-experiment, intravenous push over 2 minutes) + Propofol (intravenous push at 2mg/kg, followed by TCI mainten
Sufentanil combined with propofol group (Group S):Sufentanil (0.15µg/kg, intravenous push over 2 minutes) + Propofol (intravenous push at 2mg/kg, followed by TCI maintenance target concentration of 4µ
Sponsors
The First People's Hospital of Yunnan Province
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Females aged between 18 and 65 years; 2.Subjects in good or relatively good health (American Society of Anesthesiologists physical status classification Class I–II); 3.Scheduled to undergo hysteroscopic surgery at the First People's Hospital of Yunnan Province; 4.Voluntarily agree to participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Known allergy to opioids, propofol, or anrikefon; 2.Allergy to high-protein foods such as soybeans or milk; 3.Long-term use of opioid or non-steroidal anti-inflammatory drugs for analgesia (three or more times per week); 4.Severe cardiac, pulmonary, hepatic, or renal dysfunction; 5.Difficult airway, uncontrolled hypertension, or severe arrhythmia; 6.History of substance abuse or dependence; 7.Women who are pregnant or breastfeeding; 8.Presence of mental or cognitive impairment that prevents cooperation with study assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Median effective dose (ED50) and its 95% confidence interval; 95% effective dose (ED95);Postoperative VAS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rescue analgesia rate; mean consumption of analgesic drugs (flurbiprofen axetil);Incidence of hypoxemia;Hemodynamic parameters (SBP, DBP, MAP, HR) and incidence of adverse events (hypotension, hypertension, bradycardia, tachycardia);Incidence of postoperative nausea and vomiting (PONV);PACU stay duration;Incidence of postoperative dizziness/sedation and skin pruritus;Satisfaction score;Postoperative vaginal blood loss volume; | — |
Countries
China
Contacts
Public ContactJing Luo
The First People's Hospital of Yunnan Province
Outcome results
None listed