central disorders of hypersomnolence
Conditions
Interventions
Type 1 Narcolepsygroup:None
Healthy control group:None
Idiopathic Hypersomnia group:None
Type 2 Narcolepsy group:None
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
12 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. All study participants must meet the diagnostic criteria for Type 1 Narcolepsy (NT1), Type 2 Narcolepsy (NT2), and Idiopathic Hypersomnia (IH) as defined in the International Classification of Sleep Disorders, 3rd Edition, Revised (ICSD-3-R) published by the American Academy of Sleep Medicine (AASM). 2. Aged 12 to 60 years; 3. Score no less than 10 points on the Epworth Sleepiness Scale (ESS); 4. Able to cooperate with data collection required for the study and sign the paper-based informed consent form. Healthy control group: 1. Age and gender matched with the subjects in the NT1 group. 2. No self-reported complaints of sleep disorders. 3. Score lower than 10 points on the Epworth Sleepiness Scale (ESS). 4. Able to cooperate with data collection required for the study and sign the paper-based informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of diseases that may interfere with excessive daytime sleepiness, such as chronic sleep deprivation and untreated moderate-to-severe obstructive sleep apnea. 2. Presence of retinal dysfunction, color vision abnormalities, or neurological disorders that affect light transmission. 3. Presence of ocular diseases, including cataracts, artificial eyes, and strabismus. 4. Presence of drug/substance abuse disorders. 5. Presence of mental illnesses such as suicidal ideation. 6. Current use of medications that affect rapid eye movement (REM) sleep, e.g., anti-anxiety and antidepressant drugs. 7. Use of medications that impact alertness (e.g., modafinil, methylphenidate) within 5 half-lives prior to enrollment. 8. History of transmeridian travel or shift work within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psychomotor Vigilance Task performance metrics;Sustained Attention Response Test performance metrics;Light test performance indicators;Evaluation indices of the simulated driving task;Epworth Sleepiness Scale;Multiple Sleep Latency Test; | — |
Countries
China
Contacts
Public ContactHuan Yu
Huashan Hospital, Fudan University
Outcome results
None listed