Multimodal MRI-Based Assessment of Brain Imaging Changes Following Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) for Complex Posttraumatic Stress Disorder (CPTSD)

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600119682

Enrollment

Unknown

Registered

2026-03-02

Start date

2026-03-15

Completion date

Unknown

Last updated

2026-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complex Post-traumatic Stress Disorder

Interventions

Experimental group:Trauma-focused Cognitive-behavioural Therapy

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 18 and 45 years. 2. Meet the diagnostic criteria for Complex Posttraumatic Stress Disorder (CPTSD) as defined by the ICD-11. Comorbid diagnoses of major depressive disorder, attention-deficit/hyperactivity disorder, and/or anxiety disorders are permissible, given their frequent co-occurrence with PTSD. 3. Voluntarily provide written informed consent and demonstrate the ability to adhere to the study protocol. 4. Possess the cognitive capacity to independently comprehend the questionnaire items and comply with the study procedures, including the completion of cognitive assessments or neuroimaging examinations.

Exclusion criteria

Exclusion criteria: 1. Presence of severe or unstable physical or neurological disorders, such as stroke, epilepsy, significant cardiovascular, hepatic, or renal diseases, or autoimmune conditions. 2. Inability to communicate effectively due to unstable psychiatric conditions or intellectual disability. 3. Pregnancy or breastfeeding. 4. History of central nervous system stimulant use (including novel psychoactive substances) or prior treatment with electroconvulsive therapy. 5. Individuals deemed by the investigator to be at risk of suicidal or violent behavior during the study period. 6. Refusal to participate in the study for any other reason.

Design outcomes

Primary

Measure	Time frame
International Trauma Questionnaire;Resting-state functional magnetic resonance imaging,rs-fMRI;	—

Secondary

Measure	Time frame
The Clinical Administered PTSD Scale,CAPS;Comorbid depressive symptoms;sleep quality;	—

Countries

China

Contacts

Public ContactCailan Hou

Guangdong Mental Health Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University

houcl1975@163.com+86 135 7051 2266

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026