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A clinical observation protocol on the analgesic effect and quality of anesthesia recovery of an optimized local anesthetic regimen for transsphenoidal pituitary tumor resection

A clinical observation protocol for the analgesic effect and quality of anesthesia recovery of an optimized local anesthetic regimen used in transnasal transsphenoidal pituitary tumor resection

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600119678
Enrollment
Unknown
Registered
2026-03-02
Start date
2026-03-03
Completion date
Unknown
Last updated
2026-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pituitary tumor surgery

Interventions

Traditional Scheme Group (Group C):Incision infiltration protocol: 8mg of epinephrine + 30ml of normal saline, the gauze is infiltrated through the nose before the surgery.
Optimized local anesthetic regimen group (Group F):Incision infiltration protocol: 75mg of ropivacaine + 50µg of dexmedetomidine + 30mg of ketorolac tromethamine + 8mg of epinephrine + 30ml of normal

Sponsors

Anesthesia and Surgery Center of Guizhou Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Patients scheduled for elective transsphenoidal pituitary tumor resection in neurosurgery 2. Age 18 to 75 years old 3. ASA grade I to III 4. Signed informed consent form

Exclusion criteria

Exclusion criteria: 1. Emergency surgery 2. Patients with severe hypertension who cannot use epinephrine 3. Patients with a history of allergy to local anesthetic ropivacaine 4. Patients allergic to dexmedetomidine, with severe bradycardia, or severe atrioventricular block 5. Patients allergic to ketorolac tromethamine and non-steroidal anti-inflammatory drugs, with active peptic ulcer, recent gastrointestinal bleeding or perforation, or a history of peptic ulcer or gastrointestinal bleeding 6. Patients with liver and kidney failure 7. Patients who need to be sedated and monitored with tubes after surgery due to the special nature of the surgical method or surgical site 8. Patients who refuse to participate in the study.

Design outcomes

Secondary

MeasureTime frame
Patient recovery quality assessment QoR-15 (on the first and second days after surgery);Recovery of verbal response time;Time of extubation;Awakening period agitation score;Cough severity score during the awakening period;Total usage of opioid drugs;—

Primary

MeasureTime frame
Postoperative NRS scores (6 hours, 12 hours, 24 hours, 48 hours, 72 hours);—

Countries

China

Contacts

Public ContactKaiyun Fang

Guizhou Provincial People's Hospital

fangkaiyun@sina.cn+86 851 8593 7110

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026