Postoperative Nausea and Vomiting
Conditions
Interventions
Experimental group:5 mg dexamethasone and 1 mg droperidol
Control group:5 mg dexamethasone and saline solution
Sponsors
Weifang People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Signed the informed consent form; 2.scheduled for elective gynecological day surgery; 3.classified as ASA grade I-II; 4.BMI 18.5-27.9 kg/m^2; 5.aged 18 to 65 years.
Exclusion criteria
Exclusion criteria: 1.Known or suspected allergy to dexamethasone, droperidol, or any of their components; 2.diagnosed or suspected long QT syndrome; 3.history of clinically significant arrhythmias; 4. severe electrolyte disturbances; 5.Parkinson's disease, epilepsy, or a history of extrapyramidal symptoms induced by antipsychotic medications; 6.use of any antiemetics or corticosteroids within 24 hours prior to surgery; 7.chronic regular use of opioids; 8.history of chronic conditions predisposing to nausea and vomiting, such as gastroesophageal reflux disease or motion sickness; 9.pregnant or breastfeeding women; 10.severe hepatic or renal impairment; 11.history of alcohol or drug abuse; 12.presence of mental disorders, cognitive impairment, or language communication barriers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PONV within 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic changes during anesthesia;Incidence of adverse events during anesthesia;Changes in BIS values during anesthesia;Incidence of adverse events within 24 hours postoperatively;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactFanceng Ji
Weifang People's Hospital
Outcome results
None listed