Autism Spectrum Disorder
Conditions
Interventions
Intervention group:On the basis of original routine care (including but not limited to behavioral intervention therapy and social skills training), children will receive additional intervention with s
Sponsors
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
3 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for Autism Spectrum Disorder (ASD) as defined in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5); 2. Aged 3 to 18 years, with no gender restrictions; 3. Subjects are capable of completing all required tests and assessments; 4. Parents or legal guardians possess sufficient reading and comprehension skills to cooperate with the completion of relevant assessment scales and follow-up evaluations; 5. Parents or legal guardians provide written informed consent and participate in the study voluntarily.
Exclusion criteria
Exclusion criteria: 1. Susceptibility to malignant hyperthermia: individuals with a family history or confirmed diagnosis of malignant hyperthermia; known carriers of pathogenic mutations in RYR1, CACNA1S, or other related genes; a history of severe adverse reactions (e.g., unexplained hyperthermia, muscle rigidity, rhabdomyolysis) following previous inhalation anesthesia; 2. Active neurological diseases: frequent or poorly controlled epilepsy; a history of central nervous system disorders such as intracranial infection, space-occupying lesion, or intracranial hypertension. 3. Severe respiratory or circulatory diseases: unrepaired congenital heart disease or poor surgical outcome; chronic pulmonary disease, poorly controlled asthma, respiratory insufficiency, etc; 4. Severe electrolyte imbalance, abnormal hepatic or renal function, or metabolic disorders; 5. Use of monoamine oxidase inhibitor (MAOI) antidepressants within 2 weeks before the study; 6. Use of antipsychotic medications such as risperidone within 3 months before the study; 7. Participation in another clinical trial within 30 days before study initiation and/or during the current study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aberrant Behavior Checklist-Social Withdrawal subscale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Aberrant Behavior Checklist-Irritability subscale;Clinical Global Impression Scale; | — |
Countries
China
Contacts
Public ContactXiaoping Gu
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Outcome results
None listed