Severe Acquired Brain Injury
Conditions
Interventions
Intervention Group(HBO treatment group):None
Control Group(Conventional Clinical Therapy group):None
Sponsors
Shenzhen People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. The subject or the subject’s family member voluntarily cooperates with the study and signs the informed consent form; 2. Age: 18 to 65 years old (18 years old inclusive); 3. Patients with severe traumatic brain injury with a Glasgow Coma Scale (GCS) score of 3 to 8 points, including severe craniocerebral trauma, spontaneous intracerebral hemorrhage, massive cerebral infarction, hypoxic-ischemic encephalopathy, etc.; 4. Meeting the diagnostic criteria for severe traumatic brain injury, including a clear medical history, symptoms, physical signs, Glasgow Coma Scale (GCS) scores and imaging examination results.
Exclusion criteria
Exclusion criteria: 1. Having contraindications to HBOT, including uncontrolled epilepsy, active pneumothorax, pulmonary bullae, cerebrospinal fluid leakage due to skull base fracture, severe diseases of the heart, kidney, liver, lung, hematological system and other systems complicated with hemodynamic instability, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intracranial pressure;Regional cerebral oxygen saturation(TOI);NT-Index;Neuron specific enolase(NSE);Central nervous system specific protein(S100B);Interleukin 6(IL-6);Tumor Necrosis Factor alpha(TNF-a);Interleukin 1 beta(IL-1ß);Interleukin 10(IL-10);Lactic acid; | — |
Countries
China
Contacts
Public ContactDu Bo
Shenzhen People's Hospital
Outcome results
None listed