Overweight/Obesity Hyperhomocysteinemia
Conditions
Interventions
Calorie-Restricted Balanced Diet (CRD) Intervention Group:Calorie-Restricted Balanced Diet Protocol
Folic Acid Supplementation Group:Low-dose folic acid therapy (0.8 mg/d) with habitual diet
Sponsors
The People's Hospital of Ningxia Hui Autonomous Region
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18-65 years old 2) BMI: 24.0-40.0 kg/m^2 3) Hcy >=10 µmol/L 4) Had not taken any supplements or medications that may reduce blood homocysteine concentration for at least 1 month before the study began 5) Voluntarily participated in the study, signed the Informed Consent Form, and were able to comply with the protocol
Exclusion criteria
Exclusion criteria: 1) Pregnant or lactating women 2) Suffering from thyroid diseases or any type of cancer; with chronic kidney disease (GFR < 60 mL/min/1.73 m^2) 3) Suffering from severe diseases such as cardiovascular and cerebrovascular diseases, hepatic and renal insufficiency, malignant tumors, etc. 4) Scheduled to have any disease requiring hospitalization within the next 3 months 5) Using anti-inflammatory or immunosuppressive drugs, weight-loss drugs, having food allergies or intolerance to any dietary components, or following a vegetarian diet 6) Unable to complete the questionnaire or unsuitable for this study for other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Homocysteine;Weight;Inflammatory Cytokines;Metabolic Parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dietary Inflammatory Index (DII);Body Composition;Gut Microbiota Sequencing; | — |
Countries
China
Contacts
Public ContactZhao Qian
The People's Hospital of Ningxia Hui Autonomous Region
Outcome results
None listed