Treatment-Resistant Depression (TRD)
Conditions
Interventions
Sham Stimulation Group:Transcranial focused ultrasound (tFUS)
The sgACC Stimulation Group:Transcranial focused ultrasound (tFUS)
Sponsors
Hefei Fourth Peoples Hospital
Eligibility
Sex/Gender
All
Age
13 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1)Aged between 13 and 18 years old; (2)Of Han ethnicity; (3)Right-handed; (4)No concurrent psychiatric symptoms; (5)Meet the diagnostic criteria for treatment-resistant depressive disorder or treatment-resistant bipolar depression.
Exclusion criteria
Exclusion criteria: 1.A history of epilepsy, coma, traumatic brain injury, or psychoactive substance use; 2.Comorbid with neurological diseases or somatic diseases that may induce pathological changes of the nervous system; 3.Comorbid with severe somatic diseases; 4.resence of severe suicidal ideation or extremely high suicidal risk; 5.Having contraindications to magnetic resonance imaging (MRI).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depressive level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety level;Safety Indicators;Suicidal ideation;Social function; | — |
Countries
China
Contacts
Public ContactHui Zhong
Hefei Fourth Peoples Hospital
Outcome results
None listed