Ischemic stroke
Conditions
Interventions
HD-tDCD+iTBS Group:iTBS applied subsequent to cathodal HD-tDCS preconditioning
Sham Group:Sham iTBS applied subsequent to sham HD-tDCS preconditioning
Sham HD-tDCS+iTBS Group:iTBS applied subsequent to sham HD-tDCS preconditioning
Sponsors
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with ischemic stroke by computed tomography and/or magnetic resonance imaging, meeting the diagnostic criteria for cerebral infarction. 2. First-ever, unilateral onset, or a history of prior stroke without residual neurological deficits. 3. Stable vital signs and clear consciousness. 4. Aged 40 to 70. 5. Disease duration of 1 week to 3 months. 6. Presence of upper limb paralysis. 7. Fulg-Meyer assessment upper extremity score <= 22. 8. The patient and their family voluntarily agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. A history of epilepsy, a first-degree relative with idiopathic epilepsy, or current use of pro-convulsant medications. 2. Functional impairment or failure of major organs such as the heart, lungs, liver, or kidneys. 3. Severe cognitive or communication impairment that prevents cooperation with the study. 4. Posterior circulation infarction. 5. Presence of contraindications to TMS, including pacemakers, artificial metallic heart valves, drug-delivery pumps, insulin pumps, aneurysm clips (except titanium), or other metallic implants in the body. 6. Severe cervical spondylosis, such as marked cervical spinal canal stenosis or cervical instability. 7. Complete occlusion of the internal carotid artery. 8. Skull defects in the stimulation area. 9. Pregnant women. 10. Patients with high fever. 11. Patients with claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fulg-Meyer assessment upper extremity score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Magnetic resonance imaging;modified Barthel index;motricity index;Hong Kong edition of functional test for the hemiplegic upper extremity;safety evalution indicator;modified ashworth scale; | — |
Countries
China
Contacts
Public ContactWenjun Dai
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Outcome results
None listed