Knee osteoarthritis
Conditions
Interventions
LBB Group:Liposomal bupivacaine (20 ml, 266 mg) combined with bupivacaine hydrochloride (10 ml, 0.75%) for periarticular infiltration in knee arthroplasty
LB Group:Liposomal bupivacaine (20 ml, 266 mg) + 10 ml normal saline for periarticular infiltration in knee arthroplasty
B Group:Bupivacaine hydrochloride (30 ml, 0.25%) for periarticular infiltration in knee arthroplasty
C Group:30 ml normal saline for periarticular infiltration in knee arthroplasty
Sponsors
Affiliated hospital of north sichuan medical college
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Patients aged over 18 years; 2) Patients scheduled to undergo elective unilateral primary TKA.
Exclusion criteria
Exclusion criteria: 1) Revision knee surgery; 2) Previously diagnosed with unstable psychiatric illness; 3) Dementia; 4) Renal or hepatic disease; 5) Allergy to any component of LB or bupivacaine hydrochloride; 6) History of opioid use within the previous 7 days; and 7) History of drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative morphine consumption over 72 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS pain score; | — |
Countries
China
Contacts
Public ContactZhao Yang
Affiliated hospital of north sichuan medical college
Outcome results
None listed