Radical mastectomy for breast cancer
Conditions
Interventions
Experimental group:Target-controlled infusion (TCI) of remimazolam combined with intravenous injection of sufentanil
Sponsors
The Affiated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 45 - 65 years old. Gender: No restrictions. 18.5 kg/m^2 = 50%. 6. The patient voluntarily participated in this study and has signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those allergic to propofol, sufentanil, soybeans or eggs 2. Heart rate 100 beats per minute before anesthesia 3. Have a history of severe cardiovascular diseases, such as unstable angina pectoris, myocardial infarction within the past 6 months, severe arrhythmia (such as third-degree atrioventricular block, uncontrolled ventricular tachycardia), severe heart valve disease, or poorly controlled hypertension (systolic blood pressure > 160 mmHg and/or diastolic blood pressure > 100 mmHg) 4. Have a history of diabetes: HbA1c > 7.5% 5. Have severe liver or kidney dysfunction (Child-Pugh grade B or C; or estimated glomerular filtration rate < 60 mL/min/1.73m²) 6. Have a history of difficult airway (modified Mallory classification = grade III) 7. Have been taking drugs that affect cardiovascular responses or drug metabolism during anesthesia, such as a/ß receptor blockers, calcium channel blockers (except those who have taken them regularly for = 3 months and at a stable dose for = 1 month), strong CYP enzyme inhibitors or inducers, antipsychotic drugs, etc. 8. Have used sedative and analgesic drugs within 24 hours before the surgery 9. The proposed surgery is an emergency surgery, or the investigator judges that there are any other conditions that are not suitable for participating in this study (such as mental illness, communication disorder, history of drug or alcohol abuse) 10. Pregnant or lactating women. 11. Have respiratory dysfunction before the surgery (FEV1/FVC < 60% or arterial oxygen partial pressure < 80 mmHg)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gradient changes of target concentration in the effect compartment of ciprofol TCI;Cardiovascular response to endotracheal intubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of adverse reactions related to anesthetic induction (hypotension, bradycardia, respiratory depression, injection pain);Dose of vasoactive drugs;Hemodynamic indicators (MAP, HR, SBP) ; bispectral index (BIS);Frequency of administration of vasoactive drugs; | — |
Countries
China
Contacts
Public ContactWan Qing
The Affiated Cancer Hospital of Guizhou Medical University
Outcome results
None listed