Chronic kidney disease
Conditions
Interventions
Gold Standard: Kidney allograft biopsy pathology (Banff classification)
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Puncture Biopsy Group: Recipients who have undergone allogeneic kidney transplantation and are scheduled for ultrasound-guided puncture biopsy of the transplanted kidney; aged 18 years or above; at least 1 month after the first transplantation; the ureteral stent tube has been removed, and no surgical-related complications have occurred. In the later analysis: Based on the pathological results of the puncture biopsy, they will be classified into various subgroups of transplanted kidneys with lesions: such as rejection reaction, recurrence of primary kidney disease, other lesions, etc.; and the negative group of transplanted kidney biopsy: no clinically significant transplanted kidney lesions were found, or only mild or non-specific changes were observed. 2. Control Group: Aged 18 years or above; at least 1 month after the first transplantation; the ureteral stent tube has been removed, and no surgical-related complications have occurred; stable condition during the follow-up period: serum creatinine fluctuation <= 15% in the past 3 months, no proteinuria, no active infection or immune-related complications, and negative peripheral blood HLA antibody test (no DSA)
Exclusion criteria
Exclusion criteria: 1. Have contraindications related to renal biopsy after transplantation; 2. Have undergone at least two kidney transplants; 3. The transplanted kidney has failed; 4. Have received organ transplantation other than the kidney; 5. Have excessive obesity leading to difficulty in biopsy; 6. Have active infections that require treatment; 7. Have complications requiring surgical intervention (such as lymph fistula, vascular or ureteral stenosis, etc.); 8. Have malignant tumors or a history of malignant tumors within the past 5 years; 9. Have severe systemic diseases; 10. Are planning to conceive, are pregnant or are breastfeeding; 11. According to the investigator's judgment, the patient's compliance is poor, then they are not suitable to participate in this study; 12. Other situations that the investigator deems not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Donor-derived cell-free DNA in blood;Donor-derived cell-free DNA in urine;Pathology of transplanted kidney biopsy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine;Urinalysis; | — |
Countries
China
Contacts
Public ContactFan Yu
West China Hospital of Sichuan University
Outcome results
None listed