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Investigating the mechanism and early prediction of cognitive dysfunction after pontine ischemic stroke based on the neurovascular unit damage in the prefrontal-medial temporal lobe circuit

Investigating the mechanism and early prediction of cognitive dysfunction after pontine ischemic stroke based on the neurovascular unit damage in the prefrontal-medial temporal lobe circuit

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600119599
Enrollment
Unknown
Registered
2026-02-28
Start date
2026-03-01
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pontine ischemic stroke

Interventions

Pontine ischemic stroke:None

Sponsors

NanJing First Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Aged between 40 and 80, with an education level of >=7 years, and being right-handed;

Exclusion criteria

Exclusion criteria: 1.Diseases that may seriously affect neuropsychiatric status, such as heavy smoking, alcohol abuse, cerebral hemorrhage, drug addiction, brain trauma, Alzheimer's disease, Parkinson's disease, epilepsy, demyelinating diseases, and congenital brain malformations; 2.comorbidities such as tumors, blindness, liver cirrhosis, chronic nephritis, and coronary heart disease; 3.having received psychiatric medication within the past month; 4.contraindications to magnetic resonance imaging (MRI) scanning, including those with cardiac pacemakers, artificial heart valves, neurostimulators, aneurysm clips, as well as those with metal foreign bodies retained in the body and claustrophobia;

Design outcomes

Primary

MeasureTime frame
Function-structure coupling value, neurovascular coupling value;

Countries

China

Contacts

Public ContactHuiyou Chen

Nanjing First Hospital

chenchenxiaoyou@163.com+86 25 52271461

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026