Postoperative cognitive dysfunction
Conditions
Interventions
transfusion:None
control:None
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
19 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. age >= 18 years; 2. a patient in our hospital, to undergo elective surgery under general anaesthesia; 3. normal preoperative cognitive function; 4. patients and their families gave informed consent to participate in this study voluntarily and signed an informed consent form; 5. able to co-operate with the preoperative baseline survey, sample collection and postoperative cognitive function assessment and follow-up.
Exclusion criteria
Exclusion criteria: 1. preoperative history of cognitive dysfunction, dementia, or psychiatric illness; 2. preoperative presence of severe intestinal diseases or recent (within 3 months) use of antibiotics and other drugs that may affect intestinal flora; 3. Presence of serious perioperative complications such as severe infection, shock, and multi-organ failure; 4. a history of long-term alcohol consumption (=50g per day for more than 1 year) or substance abuse; 5. combination of severe hepatic and renal insufficiency, diabetic ketoacidosis, severe anaemia and other underlying diseases that may affect cognitive function or intestinal flora; 6. pregnant or lactating women; 7. those with an expected postoperative survival of less than 3 months, or those who are unable to complete the full follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota;Postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammation; | — |
Countries
China
Contacts
Public ContactWEI XIN
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed