postpartum depression
Conditions
Interventions
The taVNS group:Electrical stimulation was delivered through an electrode placed over the concha cavity of the left ear. In the active transcutaneous vagus nerve stimulation (taVNS) group, participant
frequency: 20 Hz) for 30 minutes, with current increasing progressively over 30 seconds until participants reported tingling, then decreasing to a level slightly below this threshold for 30 minutes.
Comfort stimulation group:In the comfort stimulation group, electrodes were placed similarly, and current was gradually increased for 30 s until participants reported tingling, then decreased to a lev
Sponsors
Hefei Maternal and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18 to 45 years old; 2. singleton pregnancy (37-42 weeks), elective cesarean section under spinal or combined spinal-epidural anesthesia; 3. No known fetal malformation or obvious abnormality; 4. American Society of Anesthesiologists (ASA) grade II-III; 5. Prenatal EPDS score =9; 6. Written informed consent; 7. Able to understand the content of the questionnaire and cooperate with the intervention and follow-up; 8. Did not participate in other studies.
Exclusion criteria
Exclusion criteria: 1. Those who have been diagnosed with severe mental illness during pregnancy or the postpartum period or are currently undergoing antidepressant treatment; 2. Combined with epilepsy, severe arrhythmia or with a pacemaker; 3. Ear infection, trauma or inability to wear stimulating electrodes; 4. Combined with other serious organic diseases or serious obstetric complications; 5. Contraindications for intraspinal puncture; 6. Follow-up for those who may be interrupted (such as those planning to live elsewhere).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of positive PPD screening at postnatal day 42 (6 weeks); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of positive PPD screening at 7 days (1 week) postpartum;Changes in EPDS total score ;VAS score ;Maternal anxiety score;Postpartum sleep quality;Quality of postpartum recovery; | — |
Countries
China
Contacts
Public ContactWeijie Wang
West District of Hefei Maternal and Child Health Hospital
Outcome results
None listed