Dental Anxiety
Conditions
Interventions
Group A:All patients received an initial dose of 2 mg remimazolam, with additional 1 mg doses as needed. Alfentanil was administered at a dose of 3 µg/kg over 30 ± 5 seconds.
Group B:All patients received an initial dose of 2 mg remimazolam, with additional 1 mg doses as needed. Alfentanil was administered at a dose of 5 µg/kg over 30 ± 5 seconds.
Group C:All patients received an initial dose of 2 mg remimazolam, with additional 1 mg doses as needed. Alfentanil was administered at a dose of 7 µg/kg over 30 ± 5 seconds.
Sponsors
The Third Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing dental extraction at the Third Affiliated Hospital of the Air Force Medical University 2.Age 60~80 years old 3. ASA classification ? ~ ? 4. Weight 18~30kg/m^2 5. Number of extracted teeth >= 3 teeth 6. Patient's consent to the study
Exclusion criteria
Exclusion criteria: 1. History of neurological disorders (cognitive impairment, brain injury, etc.) 2. Severe cardiovascular and cerebrovascular system diseases 3. Hepatic or renal impairment or acute hepatic or renal failure 4. Known hypersensitivity to sedative or local anaesthetic drugs 5. History of opioid abuse 6. Acute periodontal inflammatory period, unsuitable for dental extractions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Frankl Scale;VAS score of local anesthesia;VAS score during dental extraction;Fluctuation of vital signs;VAS score for satisfaction;Intraoperative and postoperative adverse events; | — |
Countries
China
Contacts
Public ContactBing Liu
The Third Affiliated Hospital of Air Force Medical University
Outcome results
None listed