Chronic kidney disease
Conditions
Interventions
Gold Standard:1. Glomerular filtration rate (eGFR) below 60 mL/min/1.73 m², persisting for at least three months.
2. Or eGFR is normal but kidney damage persists for at least three months, such as pr
Index test:Super-resolution ultrasound imaging and viscoelastic imaging technology
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years; clinically stable and able to cooperate with the ultrasound examination (able to hold breath for a short time/breathing cooperation, can lie flat or on the side); 2. Meets the clinical diagnostic criteria for CKD; 3. Complete routine ultrasound, STVi and SR-CEUS examinations within one week after kidney biopsy; 4. Able to obtain complete baseline data (including but not limited to Scr/eGFR, urinary albumin/proteinuria, blood pressure and main medications); 5. Clinically diagnosed as a CKD patient; 6. Sign the informed consent form, voluntarily participate in the research, and agree to cooperate with the researchers in data collectio.
Exclusion criteria
Exclusion criteria: 1.Those with kidney diseases that severely affect measurement accuracy: multiple renal cysts, multiple kidney stones, renal developmental abnormalities, renal masses, etc. 2. Pregnant and breastfeeding women; 3. Those who are unable to communicate normally and formally sign the informed consent form; 4. Those allergic to contrast agents or with clear contraindications: such as a history of severe contrast agent allergy, severe pulmonary hypertension, inability to cooperate with breath-holding or positioning, affecting image quality, etc; 5. Patients with acute renal failure or acute infectious diseases; 6. Other conditions affecting reproducibility: severe obesity (BMI>37.5 kg/m²) or extremely poor acoustic windows making effective ROI acquisition impossible, subjects deemed unsuitable for enrolment by the researcher, or those unable to complete follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emean, Vmea, Dmean ;Glomerular filtration rate;Vessel Density, Flow Velocity, FWVD ;ROC curve, ;AUC value ;sensitivity;specificity; | — |
Countries
China
Contacts
Public ContactYixin Zhu
Peking University Shenzhen Hospital
Outcome results
None listed