Autism Spectrum Disorder
Conditions
Interventions
Experimental group:Receive precision rTMS intervention based on individualized multimodal brain atlases
Sponsors
Shandong Mental Health Center
Eligibility
Sex/Gender
All
Age
3 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1.Outpatients or inpatients aged 3 to 17 years (inclusive), of any gender, right-handed; 2.Meeting the DSM-5 diagnostic criteria for ASD, confirmed by ADI-R and ADOS-2 assessments; 3.articipants agreeing to undergo scale evaluations, MRI scans, TMS therapy, and full cooperation throughout the study; guardians of participants signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Severe or unstable medical conditions, including neurological, endocrine, and rheumatic diseases, brain disorders, traumatic brain injury or surgery, and infectious diseases; 2.History of rTMS or electroconvulsive therapy within the past 3 months; 3.Contraindications to MRI scans and TMS therapy, including cardiac pacemakers, neurostimulators, artificial metal heart valves, intracranial aneurysm clips, cochlear implants, and other types of metallic implants (excluding dental braces); 4.Current severe and unstable psychiatric comorbidities (e.g., major depressive episode, acute schizophrenia, etc.), which the investigator judges may interfere with study assessments or increase participant risks; participants with stable mild comorbidities such as anxiety or attention deficit hyperactivity disorder are allowed to enroll, but their diagnosis and medication status must be documented in detail; personal or family history of epilepsy; 5.Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rush Behavior Rating Scale - Revised score;Wechsler Intelligence Scale for Children - Fifth Edition score;Aberrant Behavior Checklist score;Social Responsiveness Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the FA value of white matter fibers; | — |
Countries
China
Contacts
Public ContactDuanwei Wang
Shandong Mental Health Center
Outcome results
None listed