Depression
Conditions
Interventions
Depression:Ketogenic diet therapy
Sponsors
The Second Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with depression by the psychiatrist according to DSM-5 criteria. 2.Aged 18-65 years, with no gender restrictions. 3.Either medication-naïve for the current episode or on a stable dose of antidepressants for at least 4 weeks. 4.Hamilton Depression Rating Scale (HAMD-17) total scoren >= 17. 5.Able to complete scale assessments, understand the informed consent form, and provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1.History of intracranial organic diseases. 2.Presence of severe or unstable systemic diseases (e.g., infections, cardiac diseases, congenital immunodeficiency disorders, metabolic disorders such as pyruvate carboxylase deficiency). 3.Assessed by the investigator to be at significant risk of suicide. 4.Previous failure to respond to ketogenic diet (KD) therapy. 5.Patients who are planning pregnancy, or are currently pregnant or breastfeeding. 6.Claustrophobia, or presence of metal implants precluding magnetic resonance imaging (MRI) examination. 7.History of allergic constitution or being allergy-prone.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the cannabinoid type receptor (CB1) in the brain;Quality Assurance in KD Treatment;Clinical Symptom Assessment; Adverse Reaction Assessment;Laboratory Examination Assessment; | — |
Countries
China
Contacts
Public ContactQiaozhen Chen
The Second Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed