None
Conditions
Interventions
Group A:Intravenous remimazolam 0.3 mg/kg followed by propofol 2 mg/kg
Group B:Intravenous midazolam 0.15 mg/kg followed by propofol 2 mg/kg
Sponsors
Shanghai Children's Medical Center
Eligibility
Sex/Gender
All
Age
1 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1.aged 1-6 years, gender not restricted; 2.Body weight 8-20 kg; 3.ASA score I or II; 4.scheduled for an MRI examination under deep sedation; 5.Informed consent signed by parents/guardians.
Exclusion criteria
Exclusion criteria: 1.Diagnostic imaging expected to last longer than 1 hour; 2.Difficult airways; 3.Acute respiratory tract infection; 4.Contraindications to any of the investigated agents; 5.Abnormal liver or kidney function; 6.Neurological diseases; 7.Mental or psychological disorders; 8.A body mass index (BMI) above 30 kg/m^²
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The first-attempt sedation success rate;The overall sedation time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation onset time;Awakening time;Recovery time;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactYing Sun
Department of Anesthesiology, Shanghai Children's Medical Center
Outcome results
None listed