Depression with non-suicidal self-injury (NSSI)
Conditions
Interventions
DBT-only group:Dialectical Behavior Therapy(DBT)
iTBS-only group:iTBS therapeutic protocol (the latter being a high-frequency rTMS modality)
Combined (DBT+iTBS) group:The combined DBT and iTBS therapeutic protocol (the latter being a high-frequency rTMS modality).
Sponsors
The Second People's Hospital of Taizhou
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Participation is voluntary. For patients under the age of 18, informed consent must be obtained from a parent or guardian, who must sign the informed consent form. 2. Meet the diagnostic criteria for Major Depressive Disorder (MDD) as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), and present without psychotic features. 3. Participants must have a history of or currently exhibit non-suicidal self-injury (NSSI) behavior directed toward the body surface, capable of inducing bleeding, bruising, or pain, and meet the proposed diagnostic criteria for Nonsuicidal Self-Injury as outlined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). 4. A Patient Health Questionnaire-9 (PHQ-9) score of <=14. 5. A Generalized Anxiety Disorder-7 (GAD-7) score of <=14. 6. Aged between 12 and 18 years old.
Exclusion criteria
Exclusion criteria: 1. Exclusion of patients with epilepsy or acute cerebrovascular accident. 2. Exclude patients with severe somatic diseases—such as neurological, cardiac, hepatic, renal, endocrine, or hematological disorders—or any other conditions that may interfere with the trial assessment. 3. Exclude patients with organic mental disorders, intellectual disability, or bipolar disorder. 4. Exclude patients with alcohol or drug dependence. 5. Exclude patients with suicidal ideation or behavior. 6. Exclude patients who have received modified electroconvulsive therapy (MECT) within the past 3 months. 7. Exclude subjects with absolute contraindications to rTMS, such as the presence of metallic components in close contact with the coil (e.g., cochlear implants, implanted medication pumps, aneurysm clips).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| brain derived neurotrophic factor,BDNF;brief version of the difficulties in emotion regulation scale,DERS-16;7-item Generalized Anxiety Disorder Scale , GAD-7;Ottawa self-injury inventory,OSI;Patient Health Questionnaire-9, PHQ-9;simplified coping style question-naire,SCSQ;Beck Scale for Suicide Ideation- Chinese Version, BSI-CV; | — |
Countries
China
Contacts
Public ContactXiaojing Wang
The Second People's Hospital Of Taizhou
Outcome results
None listed