Hemodynamics of cardiac and cerebral in healthy neonates
Conditions
Interventions
Heathy neonates:None
Sponsors
Chengdu Women's and Children's Center Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1. The mother lived continuously in the same altitude region for more than 3 months during pregnancy; 2. The newborn is a singleton appropriate-for-gestational-age (AGA) neonate with a gestational age between 35+0 and 41+6 weeks; 3. Informed consent is obtained from the legal guardian.
Exclusion criteria
Exclusion criteria: Meeting any of the following criteria: 1. The legal guardian requests withdrawal from the study, or the newborn is admitted to the neonatal department for any reason within 96 hours after birth, or is discharged from the hospital against medical advice following the mother; 2. Other factors that may affect the postnatal transition period: (1) Any of the following maternal conditions during pregnancy: pre-existing diabetes/gestational diabetes, pre-existing hypertension/gestational hypertension, intrahepatic cholestasis of pregnancy, intra-amniotic infection, thyroid dysfunction complications, heart disease, connective tissue disease, prenatal diagnosis of placental dysfunction indicated by absent or reversed end-diastolic flow in the umbilical artery on fetal Doppler ultrasound, or use of prenatal antidepressant medication; (2)Any neonatal conditions (perinatal hypoxia with umbilical cord blood pH < 7.0 or Apgar score at 5 minutes < 5, or requiring resuscitation, or admission to the neonatal department, or any clinically suspected congenital anomaly); 3. Congenital heart disease detected on the initial ultrasound (excluding patent foramen ovale, arterial duct <1.5 mm, and mild pulmonary stenosis, which are considered normal variations during the transition period).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Echocardiographic hemodynamic Indices(including RV FAC, RV CO, LVEF, MAPSE/TAPSE, LV CO, Mitral/Tricuspid early diastolic inflow velocity, Mitral/Tricuspid late diastolic inflow velocity , Patent ductus arteriosus size / Shunt direction, RVET, PAAT,etc.);Cerebral hemodynamic indices(including PSV, EDV,RI,PI); | — |
Countries
China
Contacts
Public ContactJu Rong
Chengdu Women's and Children's Center Hospital
Outcome results
None listed