Sellar region tumor
Conditions
Interventions
Group A:Standardized skull base reconstruction protocol in endoscopic extended endonasal transsphenoidal approach.
Group B:Standard skull base reconstruction protocol plus the absorbable and moldable skull base support plate.
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 1-80 years, regardless of gender; 2. Diagnosed with sellar region tumors confirmed by clinical symptoms, endocrine examinations, and imaging data; 3. Planned to undergo extended endoscopic endonasal transsphenoidal approach surgery as determined by departmental discussion; 4. Karnofsky Performance Status score >= 70, with an expected survival period >= 24 months; 5. Laboratory indicators (such as liver and kidney function, blood routine, etc.) within the normal range or controllable range; 6. Signed the informed consent form and willing to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Patients with other concurrent intracranial tumors or severe brain lesions; 2. Patients scheduled to undergo craniotomy or non-extended endoscopic endonasal transsphenoidal surgery; 3. Patients with uncontrolled severe heart, lung, kidney, or liver diseases; 4. Pregnant or lactating women; 5. Patients who have previously received radiotherapy or chemotherapy; 6. Patients with active nasal infections, inflammation, or severe nasal diseases; 7. Patients with a history of severe allergies to drugs or synthetic materials; 8. Patients with extensive skull base bone destruction evaluated by preoperative imaging, for whom it is estimated that support materials cannot be used during surgery; 9. Patients with mental illness or cognitive impairment who are unable to complete follow-up or understand the purpose of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CSF Leakage Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 30-day postoperative intracranial infection rate;Utilization rates of autologous fascia, fat, and pedicled mucosal flaps;Operation duration and postoperative hospital stay;Incidence of long-term nasal complications; | — |
Countries
China
Contacts
Public ContactJun Pan
Southern Medical University Southern Hospital
Outcome results
None listed