Depressive
Conditions
Interventions
The sham aiTBS group:Sham stimulation group
The active aiTBS group:Active stimulation group
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 65 years old, gender not restricted; 2. Meets the diagnostic criteria for depression as outlined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). 3. The total score of HAMD-24 is >= 20 points; 4. Take a stable dose of antidepressant medication for at least 2 weeks; 5. The patient's physical examination, medical history, vital signs, routine tests of blood, urine and stool, liver and kidney functions, electrolytes, electrocardiogram, and electroencephalogram were all within normal ranges. 6. After fully understanding the safety of TMS, willing to actively cooperate with treatment and obtain informed consent from the patient and their family members.
Exclusion criteria
Exclusion criteria: 1. Has a history of severe physical illness and depression caused by psychoactive substances and non-substance-dependent substances; 2. Patients who have metal or electronic devices implanted in their bodies, such as intracranial metal foreign bodies, cochlear implants, cardiac pacemakers, and metal stents, etc. 3. There is a risk of epilepsy seizure. The patient has a history of brain diseases, head trauma, alcohol abuse, abnormal electroencephalogram, MRI evidence of brain structure abnormalities, or a family history of epilepsy. 4. Those with psychotic symptoms who require combined use of antipsychotic drugs; 5. Those who have received ECT, TMS or tES treatment within 3 months prior to enrollment, as well as those who have undergone systematic psychological therapy; 6. Disorders of the movement system, including Parkinson's disease, spinal cord injury, spasticity, Huntington's disease, muscular dystrophy and osteoarthritis, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of depressive symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Other symptoms of depression;motor assessment;Electrophysiological indicators including brain region activation, functional connectivity, cortical plasticity, etc.; | — |
Countries
China
Contacts
Public ContactDongsheng Zhou
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed