Ankle sprain, ankle instability, ATFL tear
Conditions
Interventions
General anesthesia:Combined intravenous and inhalation general anesthesia with preoperative peripheral nerve block
TIVA-P + PNB group:Total Intravenous Anesthesia combined with Peripheral Nerve Block
Sponsors
The second affiliated hospital of Zhejiang University school of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Full understanding of the study procedures and methods, with voluntary provision of written informed consent. 2. Aged 18 to 65 years, of either sex. 3. Scheduled for elective unilateral minimally invasive ankle surgery. 4. American Society of Anesthesiologists (ASA) physical status classification I or II. 5. Body Mass Index (BMI) between 16 and 32 kg/m^2;
Exclusion criteria
Exclusion criteria: 1. Allergy to any study medication or presence of contraindications to anesthesia. 2. Chronic Obstructive Pulmonary Disease (COPD) or unstable asthma. 3. History of difficult airway management, poorly controlled Gastroesophageal Reflux Disease (GERD), or known risk of aspiration. 4. Surgery duration expected to exceed 3 hours. 5. History of chronic opioid use prior to surgery. 6. History of severe adverse reactions to anesthesia/surgery. 7. Pregnant or breastfeeding women. 8. Patients with a history of epilepsy. 9. Severe peripheral neuropathy. 10. Other conditions deemed by the investigator to make the patient unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of stay in Phase I PACU; | — |
Secondary
| Measure | Time frame |
|---|---|
| The oral morphine equivalent (OME) of the total additional salvage consumption of acetaminophen and oxycodone within 24 hours postoperatively.;Area under the curve (AUC) of NRS pain scores within 24 hours postoperatively (measured at 2, 6, 12, 18, and 24 hours);Incidence of postoperative adverse reactions (nausea, vomiting, headache, urinary retention);Patient, surgeon, and anesthesiologist self-rating of anesthesia satisfaction;The 15-item Quality of Recovery (QoR-15) score; | — |
Countries
China
Contacts
Public ContactPan Zongyou
The second affiliated hospital of Zhejiang University school of medicine
Outcome results
None listed