Post-stroke cognitive impairment
Conditions
Interventions
sham-tACS group:Transcranial alternating current (TAC) sham stimulation, conventional medical treatment and conventional rehabilitative functional training were implemented in this group.
1. Transcra
Sponsors
Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Study I: (1) Inclusion criteria for PSCI subjects 1. Age 40-75 years old; 2. First stroke (haemorrhage/infarction) with a disease duration of =6 months; 3. Diagnosis in accordance with the "Expert Consensus on the Management of Post-Stroke Cognitive Impairment 2021" Diagnostic Points of Post-Stroke Cognitive Impairment; 4. MoCA: =26 points 4. Able to understand and co-operate with the rehabilitation assessment of this experiment; 5. The patient himself/herself or by his/her authorised delegate agreed to participate in the experiment and signed the informed consent form. (3) Inclusion criteria for healthy subjects 1. Age 40-80 years old; 2. No history of stroke; 3. MoCA: >= 26 points 4. Understand and cooperate with the rehabilitation assessment of the experiment; 5. The patient himself/herself or his/her authorised delegate agrees to participate in the experiment and signs the informed consent form. Study two: 1. Age 40-75 years old; 2. First time stroke (haemorrhage/infarction) patients with a disease duration of = 6 months; 3. Diagnosis was in accordance with the diagnostic points of Post-stroke Cognitive Impairment Diagnostic Points of the Expert Consensus on Management of Post-stroke Cognitive Impairment 2021; 4. MoCA:<26 points. 5. Stroke patients with cognitive impairment after screening by Study 2 6. No metallic implants or pacemakers in the body; 7. Able to understand and cooperate with the rehabilitation assessment and treatment of this experiment; 8. The patient himself/herself or his/her immediate family members signed the informed consent form.
Exclusion criteria
Exclusion criteria: Study I: 1. Cognitive dysfunction caused by brain tumour, senile dementia, hypothyroidism, traumatic brain injury, and other diseases. 2. Patients with sequelae of previous strokes. 3. Consciousness disorder, severe vision, hearing and speech disorders. 4.Patients with fever, electrolyte disorder or unstable vital signs. 5. Patients with severe heart, lung, liver, kidney and other important organ failure. Study II: 1. Cognitive dysfunction caused by brain tumour, senile dementia, hypothyroidism, traumatic brain injury or other diseases; 2. Patients with sequelae from previous lacunar cerebral infarction; 3. Patients with personal or family history of epilepsy or psychosis; 4. Patients with personal or family history of epilepsy or psychiatric illness; (iv) Patients with impaired consciousness, severe visual, hearing and speech disorders; 5. Patients with fever, electrolyte disorder or unstable vital signs; 6. Patients with fever, electrolyte disorders or unstable vital signs. ? Patients with severe heart, lung, liver, kidney and other important organ failure; 7. Patients with contraindications to tACS, such as localised skin injury or inflammation, cranial defects, or nociceptive hypersensitivity in the stimulated area.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA);Resting-State Electroencephalography (EEG); | — |
Secondary
| Measure | Time frame |
|---|---|
| Digit Span Test;Rey-Osterrieth Complex Figure Test (ROCF);Trail Making Test A/B(TMT); | — |
Countries
China
Contacts
Public ContactXinyang Wang
Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine
Outcome results
None listed