Hemolytic Disease of the Newborn
Conditions
Interventions
Fetomaternal hemorrhage (FMH) values >= 0.5%
Fetomaternal hemorrhage (FMH) value < 0.5%:Quantitative Detection of Fetal Red Blood Cells in Maternal Blood (FMH)
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Gestational Age: Singleton pregnant women with gestational age >= 20 weeks. 2. Clinical High-Risk Factors (meeting at least one of the following criteria): (1) Traumatic Factors: Abdominal trauma (e.g., traffic accident, fall), intrauterine fetal version, amniocentesis, chorionic villus sampling (CVS). (2) Obstetric Complications: Placental abruption, placenta previa, preeclampsia, unexplained antenatal hemorrhage, post-interventional therapy for twin-twin transfusion syndrome (TTTS). 3. Fetal Abnormalities: Fetal growth restriction (FGR), unexplained abnormal fetal heart rate monitoring, fetal hydrops, fetal anemia (elevated middle cerebral artery peak systolic velocity (MCA-PSV) detected by Doppler ultrasound). 4. High-Risk Population with Maternal-Fetal Blood Group Incompatibility: Maternal-fetal ABO or Rh-negative blood group incompatibility; positive result of the first-trimester antenatal antibody screening in pregnant women.
Exclusion criteria
Exclusion criteria: 1. Pregnant women complicated with severe hematological diseases (e.g., coagulation disorders, immune thrombocytopenic purpura) or autoimmune diseases. 2. Newborns who withdrew treatment for non-study-related reasons or were lost to follow-up after birth, resulting in missing outcome data. 3. Termination of pregnancy due to various causes. 4. Failure to complete the analysis due to unqualified core clinical data (e.g., quantitative hemorrhage test results, bilirubin levels) or unsatisfactory specimens (hemolysis, insufficient volume).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemolytic Disease of the Newborn (HDN); | — |
Secondary
| Measure | Time frame |
|---|---|
| Neonatal Anemia Severity;Neonatal Jaundice Level;Long-term Neonatal Prognosis; | — |
Countries
China
Contacts
Public ContactZhang Jun
Shanghai General Hospital
Outcome results
None listed