Postoperative nausea and vomiting
Conditions
Interventions
Amisulpride group:In the event of PONV occurring in the PACU, amisulpride injection 10 mg (diluted to 20 mL with normal saline) was administered slowly by intravenous injection.
Aprepitant group:In the event of PONV occurring in the PACU, aprepitant injection 32 mg (diluted to 20 mL with normal saline) was administered slowly by intravenous injection.
Combination therapy group of aripipitan and amisulpride:In the event of PONV occurring in the PACU, aprepitant injection 32 mg (diluted to 20 mL with normal saline) and amisulpride injection 10 mg (di
Sponsors
Central Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years, undergoing general anesthesia surgery; 2. ASA classification I-III; 3. Operation duration >=1 hour; 4. Occurrence of PONV in PACU postoperatively.
Exclusion criteria
Exclusion criteria: 1. Severe liver and kidney dysfunction, acute phase of gastrointestinal bleeding, history of arrhythmia; 2. Preoperative use of known antiemetic drugs, or presence of contraindications; 3. Presence of mental disorders or communication disorders; 4. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative nausea and vomiting 30-minute complete remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extent of PONV relief at multiple time points (1h, 2h, 4h, 6h, 24h);Adverse events following treatment administration;Intraoperative opioid consumption;Postoperative NRS pain score;Number of rescue analgesia requests;Total dose of rescue analgesics administered;Postoperative quality of recovery (QoR-15 score); Patient satisfaction score (0-10 scale); | — |
Countries
China
Contacts
Public ContactFanjun Meng
Central Hospital Affiliated to Shandong First Medical University
Outcome results
None listed