Stroke
Conditions
Interventions
Acute Ischemic Stroke Patient Cohort:None
Sponsors
Shenzhen Nanshan People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–65 years; 2. Newly developed infarct lesions on imaging; 3. Small artery occlusion subtype according to the TOAST classification, with disease duration <= 7 days; 4. NIHSS score 3–25; 5. Voluntarily signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of organic neurological diseases such as stroke, brain tumor, or traumatic brain injury; 2. Diagnosed with cognitive impairment or dementia before stroke in hospital, or suspected cognitive impairment or dementia prior to the current stroke; 3. Diagnosis of depression, bipolar disorder, or other psychiatric disorders; 4. Received thrombolysis or thrombectomy treatment; 5. Presence of metallic implants such as cardiac pacemakers or other contraindications for MRI examination; 6. Severe aphasia or other factors affecting cognitive evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| National Institutes of Health Stroke Scale;Modified Rankin Scale;Mini-Mental State Examination;Montreal Cognitive Assessment;Choroid Plexus Volume;Diffusion Tensor Image Analysis along Perivascular Space;Enlarged Perivascular Spaces; Blood Oxygen Level Dependent-Cerebrospinal Fluid;Cerebrospinal Fluid Mobility; | — |
Secondary
| Measure | Time frame |
|---|---|
| SPPL2C gene polymorphism;EFCA85 gene polymorphism; | — |
Countries
China
Contacts
Public ContactRan Lusen
Shenzhen Nanshan People’s Hospital
Outcome results
None listed