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Exploratory Study on the Impact of Peripheral Blood Metabolomic and Gut Microbiota Characteristics on Clinical Prognosis in Intensive Care Unit Patients with Acute Stress-Induced Myocardial Injury

Exploratory Study on the Impact of Peripheral Blood Metabolomic and Gut Microbiota Characteristics on Clinical Prognosis in Intensive Care Unit Patients with Acute Stress-Induced Myocardial Injury

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600119499
Enrollment
Unknown
Registered
2026-02-28
Start date
2026-02-28
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute stress-induced myocardial injury

Interventions

patients with 180-day poor prognosis group:NA
patients without 180-day poor prognosis group:NA

Sponsors

Shanghai General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years and 0.04 ng/mL and B-type natriuretic peptide (BNP) > 100 pg/mL; or ejection fraction (EF) < 50%; (3) No evidence of definite coronary artery obstruction or plaque rupture. 3. Time from diagnosis of acute stress-induced myocardial injury not exceeding 48 hours. 4. Peripheral blood and fecal samples collected within 48 hours of enrollment.

Exclusion criteria

Exclusion criteria: 1. Patients who have the history end-stage malignancy. 2. Patients who received probiotic intervention within the past 3 months. 3. Patients who have received antibiotic therapy for more than 48 hours. 4. Patients who have pregnant or breastfeeding.

Design outcomes

Primary

MeasureTime frame
Length of stay in ICU and in hospital;Incidence of serious adverse cardiovascular events within 180 days;ROC curve;Area Under Curve;

Secondary

MeasureTime frame
180-day all-cause mortality;In-hospital all-cause mortality;

Countries

China

Contacts

Public ContactZhigang Zhou

Shanghai General Hospital

zhou_zhigang1980@163.com+86 21 37798521

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026