acute heart failure
Conditions
Interventions
Control Group:GDMT Standard Heart Failure Treatment
Experimental Group:GDMT Standard Heart Failure Treatment+Take vericiguat.
Sponsors
Shanghai Tenth People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Male and female patients aged >18 years who can understand and sign informed consent forms; 2.Hospitalization due to acute heart failure (meeting at least two of the following criteria): (1) dyspnea and/or fatigue symptoms (2) physical examination found evidence of fluid retention (lung moist rale, jugular vein rage, peripheral edema) (3) chest X-ray showed pulmonary congestion (4) NT proBNP increased (sinus rhythm >= 1000 pg/ml); Atrial fibrillation >= 1600 pg/ml); 3.Left ventricular ejection fraction= 100 mmHg (4) heart rate <=120 beats per minute (5) respiratory rate <=25 beats per minute without oxygen inhalation;
Exclusion criteria
Exclusion criteria: 1.eGFR<15 ml/min/1.73m ² (using MDRD formula); 2.Severe liver dysfunction (Child Pugh C grade); 3.Simultaneously or anticipated use of the following drugs: (1) long-acting nitrate drugs, (2) other sGC stimulators, (3) phosphodiesterase-5 inhibitors (such as sildenafil, tadalafil); 4.Continuous use of intravenous inotropic drugs is required; 5.Implantable left ventricular assist device; 6.Plan to undergo a heart transplant within 3 months; 7.Severe primary pulmonary arterial hypertension; 8.acute pulmonary embolism; 9.Severe anemia (hemoglobin<60 g/dL); 10.Pregnant or lactating women; 11.Non cardiovascular diseases with an expected survival period of less than 12 months; 12.Participate in other interventional clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NT-proBNP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Left ventricular remodeling and function;6-minute walking distance;readmission due to heart failure;all-cause mortality; | — |
Countries
China
Contacts
Public ContactShuqin Zhou
Shanghai Tenth People’s Hospital
Outcome results
None listed