Growth Hormone Deficiency Following Treatment of Intracranial Tumours in Paediatric Patients
Conditions
Interventions
Growth hormone treatment group:None
No growth hormone treatment group:None
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: (1).Children who meet all of the following criteria: (1) Histologically confirmed survivors of intracranial tumours, including craniopharyngioma, germ cell tumours, gliomas, etc. (2) Age at tumour diagnosis < 18 years. (3) Completion of intracranial tumour treatment, defined as the last optimal debulking surgery or last radiotherapy session. (4) Whether or not surgery was performed. (5) Diagnosed with growth hormone deficiency. (6) Currently undergoing GH therapy for less than one year at study initiation, or requiring growth hormone therapy at present. (7) Complete key data including event-free survival rates and height measurements at baseline and follow-up periods in retrospective records.
Exclusion criteria
Exclusion criteria: Meeting any one of the following criteria: (1) Non-intracranial tumour. (2) Renal failure. (3) Growth hormone deficiency unrelated to intracranial tumours and/or their treatment. (4) Patients lacking detailed preoperative/postoperative hospital records. (5) Cancer susceptibility syndromes. (6) Other circumstances deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Event-free survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events;?Ht SDS; | — |
Countries
China
Contacts
Public ContactWang Zhujun
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed